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                思路迪肿瘤数据服务平台
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                检测信息管理平台
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                智能肿瘤数据服务平台
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              <span class="about-word">技术平台</span>
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                TECHNOLOGY PLATFORM
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      <!--肿瘤数据服务平台-->
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            <h3>肿瘤数据服务平台，服务公司内部诊断和新药研发</h3>
            <p>思路迪采用以分布式的、针对大数据的数据挖掘（Data Mining）为基础的新一代的数据分析方法以深度学习（Deep learning）为基础的新一代的人工智能算法进行数据的分析、挖掘和应用，并以此建立肿瘤数据服务平台（OncoDSP， Oncology Data Service Platform）。</p>
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            <h3>中国NGS检测行业最领先的自动化系统</h3>
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              <li><b>速度最快：</b><span>>95% 检测周期（Turn Around Time）组织8天，血液7天。</span></li>
              <li><b>质量最高：</b><span>规则引擎支持非线性复杂度的变异解读和药物推荐。</span></li>
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      <!--TINA检测信息管理平台-->
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            <p>TINA检测信息管理平台是专为医院设计的一站式肿瘤精准诊断自动分析平台可以支持思路迪现有的所有诊断产品；真正做到从生信分析到检测报告生成完全自动化，无需人工干预。</p>
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      <!--SODA智能肿瘤数据服务平台-->
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            <h3>SODA聚焦肿瘤数据，专为肿瘤临床及科研服务</h3>
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      <!--NGS测序平台-->
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             <h3>全球领先的illumina NS500高通量测序平台</h3>
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               <li>测序有效深度可达5000x（下机深度10000x)</li>
               <li>检测下限低至万分之三</li>
               <li>与市场同类产品相比，可多检出30%的真实变异</li>
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             <h3>广泛的医疗应用方向</h3>
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               <li>疾病遗传易感基因检测及注释</li>
               <li>早期筛查</li>
               <li>精准用药伴随诊断</li>
               <li>预后及动态监测 </li>
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             <h3>适用多种样本形态</h3>
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               <li>病理组织: 手术组织 、活检组织、穿刺组织</li>
               <li>体液 : &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;外周血 、唾液 、其他体液</li>
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             <h3>严格的质量、技术认证和认可</h3>
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               <li>最先进的多重PCR技术实现半定量的TCR检测</li>
               <li>高度的可重复性确保检测结果的稳定性。</li>
               <li>优化的生物信息学分析最大限度地展现TCR克隆的信息。</li>
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      <!--数字微滴PCR平台-->
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              <h3>美国Bio-Rad公司的QX200™ Droplet Digital™ PCR System</h3>
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                <li>所需样本量少，只需5毫升病人全血或病理组织</li>
                <li>可实现单拷贝检测</li>
                <li>0.02% LoD (20000拷贝背景)</li>
                <li>低背景，某些位点可达100% 特异性</li>
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              <h3>广泛的医疗应用方向</h3>
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                <li>早期筛查</li>
                <li>精准用药伴随诊断</li>
                <li>预后及动态监测</li>
                <li>辅助诊断</li>
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              <h3>适用多种样本形态</h3>
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                <li>病理组织</li>
                <li>ctDNA（血液）</li>
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              <h3>严格的质量、技术认证和认可</h3>
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                <li>报告周期短至3天，利于癌症患者快速用药决策</li>
                <li>无需标准品，无需标准曲线，无cq值</li>
                <li>不受PCR效率影响</li>
                <li>绝对定量</li>
                <li>更高的灵敏度和重复性，检测下限可低至单拷贝</li>
                <li>高分通过中国卫计委ddPCR室间质评</li>
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              <h3>单细胞测序</h3>
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                <li>测单细胞基因组DNA高通量测序</li>
                <li>单细胞全长mRNA高通量测序</li>
                <li>单细胞3’端mRNA高通量测序</li>
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              <h3>临床转化运用的多功能平台</h3>
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                <li>鉴定肿瘤内细胞间的相互影响</li>
                <li>鉴定治疗过程中肿瘤演化与抗药性</li>
                <li>鉴定肿瘤内免疫细胞活性调控机制</li>
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              <h3>适用多种样本形态</h3>
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                <li>新鲜组织样本</li>
                <li>冷冻保存组织单细胞悬液</li>
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              <h3>我们的优势</h3>
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                <li>平台负责人拥有11年的利用临床样本探索临床问题的科研</li>
                <li>能力以及一手scRNA测序经验</li>
                <li>该平台对单细胞活性、cDNA以及测序数据建立了严格QC准则</li>
                <li>完整的单细胞数据分析系统</li>
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      <!--优化发光平台-->
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              <h3>全球领先的Luminex200 流式荧光技术</h3>
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                <li>通量高，一次最多同时检测100个指标</li>
                <li>应用领域广，既能检测蛋白，又能检测核酸</li>
                <li>检测区间长，跨至少6个数量级</li>
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              <h3>广泛的医疗应用方向</h3>
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                <li>体外诊断</li>
                <li>伴随诊断</li>
                <li>早期筛查</li>
                <li>预后及动态监测</li>
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              <h3>适用多种样本形态</h3>
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                <li>血浆、血清的蛋白</li>
                <li>外泌体的膜蛋白和内含蛋白</li>
                <li>唾液及其他体液中的蛋白</li>
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              <h3>我们的优势</h3>
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                <li>多名博士组成的强大的技术研发团队</li>
                <li>强大的数据分析团队</li>
                <li>具有丰富的临床检测经验</li>
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              <h3>单细胞测序</h3>
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                <li>T细胞受体β链CDR3区域高通量测序</li>
                <li>检测下限低至万分之一</li>
                <li>优良的稳定性和可重复性</li>
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              <h3>临床转化运用的多功能平台</h3>
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                <li>肿瘤免疫治疗生物标记物研究</li>
                <li>药物响应的疗效评估</li>
                <li>细胞治疗和疫苗评估</li>
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              <h3>适用样本</h3>
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                <li>血液</li>
                <li>PBMC</li>
                <li>新鲜组织</li>
                <li>TILs</li>
                <li>纯化的T细胞</li>
                <li>从T细胞中提取的RNA</li>
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              <h3>我们的优势</h3>
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                <li>最先进的多重PCR技术实现半定量的TCR检测</li>
                <li>高度的可重复性确保检测结果的稳定性</li>
                <li>优化的生物信息学分析最大限度地展现TCR克隆的信息</li>
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              <h3>自主研发的外泌体分离方法</h3>
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                <li>操作简单，无需超速离心，省时省力</li>
                <li>纯度高，富集量大，应用范围广</li>
                <li>获取的外泌体结构和功能完整</li>
                <li>稳定性好，便于运输，便于保存</li>
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              <h3>广泛的医疗应用方向</h3>
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                <li>体外诊断</li>
                <li>伴随诊断</li>
                <li>早期筛查</li>
                <li>预后及动态监测</li>
              </ul>
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              <h3>适用多种样本形态</h3>
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                <li>血液</li>
                <li>细胞培养上清</li>
                <li>其他体液</li>
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              <h3>我们的优势</h3>
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                <li>具有自主开发的血清/血浆外泌体分离试剂，该分离试剂效率高，操作简单，结果高度可重复</li>
                <li>提供外泌体分离之后内含物（蛋白、核酸等）的释放与检测等配套解决方案</li>
                <li>系统的生物信息分析流程</li>
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            <p>在过去几年，思路迪建成了全球最大的肝癌原代肿瘤细胞库PDC（超过1500株肝癌原代细胞，为现有细胞系规模30倍）和最大的肝癌PDX板块 （~300个），数量还在不断快速攀升。此外，还在构建其他中国高发性癌症，如食管癌、肺癌、结直肠癌、头颈部肿瘤和胆囊癌的原代细胞库。</p>
            <p>这些细胞株来源于中国病人，包含病人肿瘤组织的基因信息。我们可以用大通量(数百株)细胞株药敏反应测试，使得临床前在大规模不同个体中评估药物反应和适应症这一 之前几乎不可能的步骤变为现实。同时，我们可以在细胞平台的基础上对敏感群体进行高通量测序和肿瘤基因组大数据分析，针对其共同信号通路寻找生物标志物。在后续的临床研究中，由于已经知道药物在肿瘤病人中大致有效率，并有明确的生物标志物找到这些有效病人群体。因而可以预见，以患者基因组大数据出发的逆向思维指导的新药开发，将大大提高成功率，降低开发风险。</p>
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